Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human immunodeficiency …

NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

The unconventional role of HLA-E: The road less traveled

EJ Grant, AT Nguyen, CA Lobos, C Szeto… - Molecular …, 2020 - Elsevier
Abstract Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic
molecules in humans. This high degree of polymorphism endows HLA molecules with the …

HLA‐E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome

T Kraemer, AA Celik, T Huyton… - Stem cells …, 2015 - Wiley Online Library
The HLA‐E locus encodes a nonclassical class Ib molecule that serves many immune
functions from inhibiting NK cells to activating CTLs. Structural analysis of HLA‐E/NKG2A …

The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch

AA Celik, T Kraemer, T Huyton, R Blasczyk… - Immunogenetics, 2016 - Springer
Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated
killing. Low in polymorphisms, two alleles are widely expressed among diverse populations …

Clinical and immunological significance of HLA‐E in stem cell transplantation and cancer

L Wieten, NM Mahaweni, CEM Voorter… - Tissue …, 2014 - Wiley Online Library
Human leukocyte antigen‐E (HLA‐E) is a nonclassical HLA class I molecule that canonically
binds peptides derived from the leader sequence of classical HLA class I. HLA‐E can also …

HLA-E: exploiting pathogen-host interactions for vaccine development

HR Sharpe, G Bowyer, S Brackenridge… - Clinical & …, 2019 - academic.oup.com
Viruses, when used as vectors for vaccine antigen delivery, can induce strong cellular and
humoral responses against target epitopes. Recent work by Hansen et al. describes the use …

DapNet-HLA: adaptive dual-attention mechanism network based on deep learning to predict non-classical HLA binding sites

Y Jing, S Zhang, H Wang - Analytical Biochemistry, 2023 - Elsevier
Human leukocyte antigen (HLA) plays a vital role in immunomodulatory function. Studies
have shown that immunotherapy based on non-classical HLA has essential applications in …

HLA‐E: a novel player for histocompatibility

T Kraemer, R Blasczyk… - Journal of Immunology …, 2014 - Wiley Online Library
The classical class I human leukocyte antigens (HLA‐A,‐B, and‐C) present allele‐specific
self‐or pathogenic peptides originated by intracellular processing to CD8+ immune effector …

HLA‐E allelic genotype correlates with HLA‐E plasma levels and predicts early progression in chronic lymphocytic leukemia

B Wagner, F da Silva Nardi, S Schramm, T Kraemer… - Cancer, 2017 - Wiley Online Library
BACKGROUND Human leukocyte antigen‐E (HLA‐E) is a nonclassical major
histocompatibility complex class I molecule that recently came into sharper focus as a …

HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus

EC Castelli, P Gerasimou, MA Paz, J Ramalho… - Molecular …, 2017 - Elsevier
The HLA-G molecule presents immunomodulatory properties that might inhibit immune
responses when interacting with specific Natural Killer and T cell receptors, such as …