Ethanolic leaf extract of Datura stramonium attenuates methotrexate-induced biochemical alterations in Wistar Albino rats
Objectives Methotrexate (MTX) is a commonly used anti-cancer drug. However, its usage
could lead to various biochemical dysregulations culminating in organ toxicity. Globally …
could lead to various biochemical dysregulations culminating in organ toxicity. Globally …
[HTML][HTML] Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and …
Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in
different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical …
different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical …
Ligand-based design and synthesis of N'-Benzylidene-3, 4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and …
RR Ezz Eldin, MA Saleh, MH Alotaibi… - Journal of Enzyme …, 2022 - Taylor & Francis
Herein, a series of N'-benzylidene-3, 4-dimethoxybenzohydrazide derivatives were
designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial …
designed and synthesised to target the multidrug efflux pump (MATE). The antibacterial …
Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity
A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Naunyn-schmiedeberg's …, 2024 - Springer
The objective of this study was to investigate whether the neurotoxic effects caused by
methotrexate (MTX), a frequently used chemotherapy drug, could be improved by …
methotrexate (MTX), a frequently used chemotherapy drug, could be improved by …
An overview of the direct interaction of synthesized silver nanostructures and enzymes
H Lei, F Liu, M Jia, H Ni, Y Han, J Chen, H Wang… - International Journal of …, 2024 - Elsevier
Silver nanoparticles (AgNPs) have drawn a lot of attention from a variety of fields, particularly
the biological and biomedical sciences. As a result, it is acknowledged that AgNPs' direct …
the biological and biomedical sciences. As a result, it is acknowledged that AgNPs' direct …
Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases
C Bi, W Han, J Yu, H Zhang, G Xing, Z Liu - Heliyon, 2023 - cell.com
Background Liver diseases are a spectrum of diseases that include hepatic steatosis,
nonalcoholic fatty liver disease, hepatitis, liver fibrosis, cirrhosis, and hepatic cancer. These …
nonalcoholic fatty liver disease, hepatitis, liver fibrosis, cirrhosis, and hepatic cancer. These …
Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis—The Role of Drug Efflux Transporters
Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors
and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress …
and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress …
[HTML][HTML] Ameliorating effects of ramelteon on oxidative stress, inflammation, apoptosis, and autophagy markers in methotrexate-induced cerebral toxicity
R Aslankoc, M Savran, DK Doğuç… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): Methotrexate (MTX) is a widely used chemotherapeutic agent that, however, is
known to have serious side effects such as neurotoxicity. In the present study, we aimed to …
known to have serious side effects such as neurotoxicity. In the present study, we aimed to …
Evaluation of the ameliorative potency of spirulina platensis against cerebellar damage induced by methotrexate in male rats: histopathological, ultrastructural …
EH Kandil, HAA elSamie, AH AbdElrahman… - Beni-Suef University …, 2024 - Springer
Background Methotrexate (MTX), a drug utilized in cancer and rheumatoid arthritis
treatment, is associated with acute and chronic neurodegenerative alterations. Spirulina …
treatment, is associated with acute and chronic neurodegenerative alterations. Spirulina …
Astrocytes are active: An information theoretic approach reveals differences in Ca2+ signaling patterns among distinct astrocyte subtypes
NJ Mennona, B Barile, H Kang, V Benfenati… - bioRxiv, 2023 - biorxiv.org
The discovery that astrocytes are an active, rather than a passive, component of the brain
has ushered in a paradigm shift in thinking about how the brain processes information …
has ushered in a paradigm shift in thinking about how the brain processes information …