Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …

Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …

Recent evidence suggests alterations in the gut microbiota-brain axis may drive cognitive
impairment with aging. In the present study, we observed that prolonged administration of D …

Background The kynurenine pathway (KP) is gaining more attention as a common pathway
involved in age-related conditions. However, which changes in the KP occur due to normal …

Serum neurofilament light chain (NFL), a potential general biomarker for neurodegenerative
diseases, is not specific enough to differentiate neurodegenerative diseases from other …

Background Schizophrenia (SCZ) is a serious psychiatric disorder. Metabolite disturbance is
an important pathogenic factor in schizophrenic patients. In this study, we aim to identify …

Fluoride is widely present in the environment. Excessive fluoride exposure leads to fluorosis,
which has become a global public health problem and will cause damage to various organs …

Alzheimer's disease (AD) pathogenesis involves dysregulation in diverse biochemical
processes. Nevertheless, plasma tau phosphorylated at threonine 181 (P‐tau181), a …