Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Bladder cancer (BC) has a 70% telomerase reverse transcriptase (TERT or hTERT in
humans) promoter mutation prevalence, commonly at− 124 base pairs, and this is …

Active telomerase is essential for stem cells and most cancers to maintain telomeres. The
enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the …

Cancer is a clonal disease, ie, all tumor cells within a malignant lesion trace their lineage
back to a precursor somatic cell that acquired oncogenic mutations during development and …

Telomere maintenance is a hallmark of human cancer that enables replicative immortality.
Most cancer cells acquire telomere maintenance by telomerase activation through …

The spatial partitioning of the transcriptome in the cell is an important form of gene-
expression regulation. Here, we address how intron retention influences the spatio-temporal …

Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in
hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT …

Telomerase-based therapeutic cancer vaccines (TCVs) have been under clinical
investigation for the past two decades. Despite past failures, TCVs have gained renewed …