Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

The mammalian ovary is an extremely dynamic organ in which a large majority of follicles
are effectively eliminated throughout their reproductive life. Due to the numerous efforts of …

Phthalates are commonly used as plasticizers in the manufacturing of flexible polyvinyl
chloride products. Large production volumes of phthalates and their widespread use in …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Mammalian ovaries consist of follicles as basic functional units. The total number of ovarian
follicles is determined early in life, and the depletion of this pool leads to reproductive …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

The delay in childbearing is an important societal change contributing to an increasing
incidence of subfertility. The prevailing concept of female reproductive ageing assumes that …

A basic doctrine of reproductive biology is that most mammalian females lose the capacity
for germ-cell renewal during fetal life, such that a fixed reserve of germ cells (oocytes) …

Calcium and cyclic nucleotides have crucial roles in mammalian fertilization, but the
molecules comprising the Ca2+-permeation pathway in sperm motility are poorly …