Parkinson's disease drug therapies in the clinical trial pipeline: 2020
K McFarthing, S Buff, G Rafaloff… - Journal of …, 2020 - content.iospress.com
Background: The majority of current pharmacological treatments for Parkinson's disease
(PD) were approved for clinical use in the second half of the last century and they only …
(PD) were approved for clinical use in the second half of the last century and they only …
A precision medicine initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling
After intense scientific exploration and more than a decade of failed trials, Alzheimer's
disease (AD) remains a fatal global epidemic. A traditional research and drug development …
disease (AD) remains a fatal global epidemic. A traditional research and drug development …
Bioinformatics mining and modeling methods for the identification of disease mechanisms in neurodegenerative disorders
M Hofmann-Apitius, G Ball, S Gebel… - International journal of …, 2015 - mdpi.com
Since the decoding of the Human Genome, techniques from bioinformatics, statistics, and
machine learning have been instrumental in uncovering patterns in increasing amounts and …
machine learning have been instrumental in uncovering patterns in increasing amounts and …
A census of disease ontologies
For centuries, humans have sought to classify diseases based on phenotypic presentation
and available treatments. Today, a wide landscape of strategies, resources, and tools exist …
and available treatments. Today, a wide landscape of strategies, resources, and tools exist …
PCLiON: An ontology for data standardization and sharing of prostate cancer associated lifestyles
Abstract Background Researches on Lifestyle medicine (LM) have emerged in recent years
to garner wide attention. Prostate cancer (PCa) could be prevented and treated by positive …
to garner wide attention. Prostate cancer (PCa) could be prevented and treated by positive …
Evaluating ontology-based pd monitoring and alerting in personal health knowledge graphs and graph neural networks
In the realm of Parkinson's Disease (PD) research, the integration of wearable sensor data
with personal health records (PHR) has emerged as a pivotal avenue for patient alerting and …
with personal health records (PHR) has emerged as a pivotal avenue for patient alerting and …
PCAO2: an ontology for integration of prostate cancer associated genotypic, phenotypic and lifestyle data
Disease ontologies facilitate the semantic organization and representation of domain-
specific knowledge. In the case of prostate cancer (PCa), large volumes of research results …
specific knowledge. In the case of prostate cancer (PCa), large volumes of research results …
[HTML][HTML] A natural language processing system for the efficient updating of highly curated pathophysiology mechanism knowledge graphs
NS Babaiha, H Elsayed, B Zhang, A Kaladharan… - Artificial Intelligence in …, 2023 - Elsevier
Background Biomedical knowledge graphs (KG) have become crucial for describing
biological findings in a structured manner. To keep up with the constantly changing flow of …
biological findings in a structured manner. To keep up with the constantly changing flow of …
Ontology-Driven Knowledge Sharing in Alzheimer's Disease Research
S Lazarova, D Petrova-Antonova, T Kunchev - Information, 2023 - mdpi.com
Alzheimer's disease is a debilitating neurodegenerative condition which is known to be the
most common cause of dementia. Despite its rapidly growing prevalence, medicine still …
most common cause of dementia. Despite its rapidly growing prevalence, medicine still …
[PDF][PDF] The Representation of Causality and Causation with Ontologies: A Systematic Literature Review
Objective: To explore how disease-related causality is formally represented in current
ontologies and identify their potential limitations. Methods: We conducted a systematic …
ontologies and identify their potential limitations. Methods: We conducted a systematic …