Parkinson's disease drug therapies in the clinical trial pipeline: 2020

K McFarthing, S Buff, G Rafaloff… - Journal of …, 2020 - content.iospress.com
Background: The majority of current pharmacological treatments for Parkinson's disease
(PD) were approved for clinical use in the second half of the last century and they only …

A precision medicine initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling

H Hampel, SE O'Bryant, S Durrleman, E Younesi… - …, 2017 - Taylor & Francis
After intense scientific exploration and more than a decade of failed trials, Alzheimer's
disease (AD) remains a fatal global epidemic. A traditional research and drug development …

Bioinformatics mining and modeling methods for the identification of disease mechanisms in neurodegenerative disorders

M Hofmann-Apitius, G Ball, S Gebel… - International journal of …, 2015 - mdpi.com
Since the decoding of the Human Genome, techniques from bioinformatics, statistics, and
machine learning have been instrumental in uncovering patterns in increasing amounts and …

A census of disease ontologies

MA Haendel, JA McMurry, R Relevo… - Annual Review of …, 2018 - annualreviews.org
For centuries, humans have sought to classify diseases based on phenotypic presentation
and available treatments. Today, a wide landscape of strategies, resources, and tools exist …

PCLiON: An ontology for data standardization and sharing of prostate cancer associated lifestyles

Y Chen, C Yu, X Liu, T Xi, G Xu, Y Sun, F Zhu… - International Journal of …, 2021 - Elsevier
Abstract Background Researches on Lifestyle medicine (LM) have emerged in recent years
to garner wide attention. Prostate cancer (PCa) could be prevented and treated by positive …

Evaluating ontology-based pd monitoring and alerting in personal health knowledge graphs and graph neural networks

N Zafeiropoulos, P Bitilis, GE Tsekouras, K Kotis - Information, 2024 - mdpi.com
In the realm of Parkinson's Disease (PD) research, the integration of wearable sensor data
with personal health records (PHR) has emerged as a pivotal avenue for patient alerting and …

PCAO2: an ontology for integration of prostate cancer associated genotypic, phenotypic and lifestyle data

C Yu, H Zong, Y Chen, Y Zhou, X Liu… - Briefings in …, 2024 - academic.oup.com
Disease ontologies facilitate the semantic organization and representation of domain-
specific knowledge. In the case of prostate cancer (PCa), large volumes of research results …

[HTML][HTML] A natural language processing system for the efficient updating of highly curated pathophysiology mechanism knowledge graphs

NS Babaiha, H Elsayed, B Zhang, A Kaladharan… - Artificial Intelligence in …, 2023 - Elsevier
Background Biomedical knowledge graphs (KG) have become crucial for describing
biological findings in a structured manner. To keep up with the constantly changing flow of …

Ontology-Driven Knowledge Sharing in Alzheimer's Disease Research

S Lazarova, D Petrova-Antonova, T Kunchev - Information, 2023 - mdpi.com
Alzheimer's disease is a debilitating neurodegenerative condition which is known to be the
most common cause of dementia. Despite its rapidly growing prevalence, medicine still …

[PDF][PDF] The Representation of Causality and Causation with Ontologies: A Systematic Literature Review

S Sawesi, M Rashrash, O Dammann - Online Journal of Public Health …, 2022 - ojphi.jmir.org
Objective: To explore how disease-related causality is formally represented in current
ontologies and identify their potential limitations. Methods: We conducted a systematic …