Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

TC Silva, M Eppink, M Ottens - Journal of Chemical …, 2022 - Wiley Online Library
Process development in the biotech industry leads to investments around hundred of
millions of dollars. It is important to mitigate costs without neglecting the quality of process …

Bioremediation of dyes: a brief review of bioreactor performance

H Tiwari, RK Sonwani, RS Singh - Environmental Technology …, 2023 - Taylor & Francis
It has long been known that the textile industry generates a massive amount of synthetic
waste across the globe. Dye-containing wastewater is carcinogenic, mutagenic, recalcitrant …

[HTML][HTML] High-throughput microbioreactor provides a capable tool for early stage bioprocess development

M Fink, M Cserjan-Puschmann, D Reinisch… - Scientific reports, 2021 - nature.com
Tremendous advancements in cell and protein engineering methodologies and
bioinformatics have led to a vast increase in bacterial production clones and recombinant …

[HTML][HTML] Measurement of respiration and acidification rates of mammalian cells in thermoplastic microfluidic devices

B Müller, P Sulzer, M Walch, H Zirath, T Buryška… - Sensors and Actuators B …, 2021 - Elsevier
Luminescent chemical sensors have been proven to be a valuable asset in cell cultures and
generally in microbiological studies. We present microfluidic cell culture devices with …

Rapid microfluidics prototyping through variotherm desktop injection molding for multiplex diagnostics

GD Suarez, S Bayer, YYK Tang, DA Suarez… - Lab on a Chip, 2023 - pubs.rsc.org
In this work, we demonstrate an inexpensive method of prototyping microfluidics using a
desktop injection molding machine. A centrifugal microfluidic device with a novel central …

[HTML][HTML] 3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation

LJ Frey, D Vorländer, H Ostsieker, D Rasch, JL Lohse… - Scientific reports, 2021 - nature.com
With the technological advances in 3D printing technology, which are associated with ever-
increasing printing resolution, additive manufacturing is now increasingly being used for …

[HTML][HTML] Advanced multi-modal, multi-analyte optochemical sensing platform for cell analysis

AV Zhdanov, L Li, P Yang, AO Shkirdova… - Sensors and Actuators B …, 2022 - Elsevier
Cell analysis by optochemical sensing represents large and important niche in life and
biomedical sciences. We present advanced multi-modal, multi-analyte sensing platform and …

Real-time monitoring and control of CHO cell apoptosis by in situ multifrequency scanning dielectric spectroscopy

F Ma, A Zhang, D Chang, OD Velev, K Wiltberger… - Process …, 2019 - Elsevier
Process control strategies based on the physiological status of cells have recently been
used to enhance mammalian cell culture productivity and robustness. In this study, we …

[HTML][HTML] Online 2D fluorescence monitoring in microtiter plates allows prediction of cultivation parameters and considerable reduction in sampling efforts for parallel …

C Berg, N Ihling, M Finger, O Paquet-Durand… - Bioengineering, 2022 - mdpi.com
Multi-wavelength (2D) fluorescence spectroscopy represents an important step towards
exploiting the monitoring potential of microtiter plates (MTPs) during early-stage bioprocess …

[HTML][HTML] 2-Stage microfermentations

S Li, Z Ye, EA Moreb, R Menacho-Melgar… - Metabolic Engineering …, 2024 - Elsevier
Cell based factories can be engineered to produce a wide variety of products. Advances in
DNA synthesis and genome editing have greatly simplified the design and construction of …