Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing
TC Silva, M Eppink, M Ottens - Journal of Chemical …, 2022 - Wiley Online Library
Process development in the biotech industry leads to investments around hundred of
millions of dollars. It is important to mitigate costs without neglecting the quality of process …
millions of dollars. It is important to mitigate costs without neglecting the quality of process …
Bioremediation of dyes: a brief review of bioreactor performance
It has long been known that the textile industry generates a massive amount of synthetic
waste across the globe. Dye-containing wastewater is carcinogenic, mutagenic, recalcitrant …
waste across the globe. Dye-containing wastewater is carcinogenic, mutagenic, recalcitrant …
[HTML][HTML] High-throughput microbioreactor provides a capable tool for early stage bioprocess development
M Fink, M Cserjan-Puschmann, D Reinisch… - Scientific reports, 2021 - nature.com
Tremendous advancements in cell and protein engineering methodologies and
bioinformatics have led to a vast increase in bacterial production clones and recombinant …
bioinformatics have led to a vast increase in bacterial production clones and recombinant …
[HTML][HTML] Measurement of respiration and acidification rates of mammalian cells in thermoplastic microfluidic devices
B Müller, P Sulzer, M Walch, H Zirath, T Buryška… - Sensors and Actuators B …, 2021 - Elsevier
Luminescent chemical sensors have been proven to be a valuable asset in cell cultures and
generally in microbiological studies. We present microfluidic cell culture devices with …
generally in microbiological studies. We present microfluidic cell culture devices with …
Rapid microfluidics prototyping through variotherm desktop injection molding for multiplex diagnostics
GD Suarez, S Bayer, YYK Tang, DA Suarez… - Lab on a Chip, 2023 - pubs.rsc.org
In this work, we demonstrate an inexpensive method of prototyping microfluidics using a
desktop injection molding machine. A centrifugal microfluidic device with a novel central …
desktop injection molding machine. A centrifugal microfluidic device with a novel central …
[HTML][HTML] 3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation
LJ Frey, D Vorländer, H Ostsieker, D Rasch, JL Lohse… - Scientific reports, 2021 - nature.com
With the technological advances in 3D printing technology, which are associated with ever-
increasing printing resolution, additive manufacturing is now increasingly being used for …
increasing printing resolution, additive manufacturing is now increasingly being used for …
[HTML][HTML] Advanced multi-modal, multi-analyte optochemical sensing platform for cell analysis
AV Zhdanov, L Li, P Yang, AO Shkirdova… - Sensors and Actuators B …, 2022 - Elsevier
Cell analysis by optochemical sensing represents large and important niche in life and
biomedical sciences. We present advanced multi-modal, multi-analyte sensing platform and …
biomedical sciences. We present advanced multi-modal, multi-analyte sensing platform and …
Real-time monitoring and control of CHO cell apoptosis by in situ multifrequency scanning dielectric spectroscopy
Process control strategies based on the physiological status of cells have recently been
used to enhance mammalian cell culture productivity and robustness. In this study, we …
used to enhance mammalian cell culture productivity and robustness. In this study, we …
[HTML][HTML] Online 2D fluorescence monitoring in microtiter plates allows prediction of cultivation parameters and considerable reduction in sampling efforts for parallel …
Multi-wavelength (2D) fluorescence spectroscopy represents an important step towards
exploiting the monitoring potential of microtiter plates (MTPs) during early-stage bioprocess …
exploiting the monitoring potential of microtiter plates (MTPs) during early-stage bioprocess …
[HTML][HTML] 2-Stage microfermentations
Cell based factories can be engineered to produce a wide variety of products. Advances in
DNA synthesis and genome editing have greatly simplified the design and construction of …
DNA synthesis and genome editing have greatly simplified the design and construction of …