Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

To understand disease pathophysiologies, models that recapitulate human functions are
necessary. In vitro models that consist of human cells are preferred to ones using animal …

In vitro models of liver (patho) physiology, new technologies, and experimental approaches
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …

Cardiovascular disease is a major cause of mortality worldwide, and current preclinical
models including traditional animal models and 2D cell culture models have limitations in …

Physiologically relevant and broadly applicable liver cell culture platforms are of great
importance in both drug development and disease modeling. Organ-on-a-chip systems offer …

Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and
functionality of human organs on a microfluidic chip, is undergoing significant technological …

Liver models are vital for the liver diseases and drug research as many novel drugs.
However, traditional liver models cannot meet this need, mainly because they cannot …

The liver is a multifunctional organ and the metabolic center of the human body. Most drugs
and toxins are metabolized in the liver, resulting in varying degrees of hepatotoxicity. The …