Effector and memory T-cell differentiation: implications for vaccine development

SM Kaech, EJ Wherry, R Ahmed - Nature Reviews Immunology, 2002 - nature.com
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and …

Personalized vaccinology: a review

GA Poland, IG Ovsyannikova, RB Kennedy - Vaccine, 2018 - Elsevier
At the current time, the field of vaccinology remains empirical in many respects. Vaccine
development, vaccine immunogenicity, and vaccine efficacy have, for the most part …

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Y Minokoshi, YB Kim, OD Peroni, LGD Fryer, C Müller… - Nature, 2002 - nature.com
Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food
intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of …

Enhancing SIV-specific immunity in vivo by PD-1 blockade

V Velu, K Titanji, B Zhu, S Husain, A Pladevega, L Lai… - Nature, 2009 - nature.com
Chronic immunodeficiency virus infections are characterized by dysfunctional cellular and
humoral antiviral immune responses,,. As such, immune modulatory therapies that enhance …

[图书][B] Molecular biotechnology: principles and applications of recombinant DNA

BR Glick, CL Patten - 2022 - books.google.com
Molecular Biotechnology Molecular Biotechnology Principles and Applications of
Recombinant DNA SIXTH EDITION An authoritative introduction to the fast-changing world …

A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection

NK Routhu, S Gangadhara, L Lai… - Science …, 2022 - science.org
SARS-CoV-2 vaccines should induce broadly cross-reactive humoral and T cell responses
to protect against emerging variants of concern (VOCs). Here, we inactivated the furin …

Heterologous prime–boost vaccination

S Lu - Current opinion in immunology, 2009 - Elsevier
An effective vaccine usually requires more than one time immunization in the form of prime–
boost. Traditionally the same vaccines are given multiple times as homologous boosts. New …

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

JW Shiver, TM Fu, L Chen, DR Casimiro, ME Davies… - Nature, 2002 - nature.com
Recent studies of human immunodeficiency virus type 1 (HIV-1) infection in humans and of
simian immunodeficiency virus (SIV) in rhesus monkeys have shown that resolution of the …

Anti-PD-L1 antibodies and uses therefor

GJ Freeman, R Ahmed, TD Jones, FJ Carr… - US Patent …, 2013 - Google Patents
JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z, 12Z-octadecadienoyl)-sn-
glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC (= O) OC [C …

[图书][B] HIV and the pathogenesis of AIDS.

JA Levy - 1994 - cabidigitallibrary.org
This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …