Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Neurons in most animals live a very long time relative to the half-lives of all of the proteins
that govern excitability and synaptic transmission. Consequently, homeostatic mechanisms …

Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …

Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

N-Methyl-d-aspartate receptor (NMDAR)-dependent synaptic plasticity is a strong candidate
to mediate learning and memory processes that require the hippocampus. This plasticity is …

Transient elevations in cytoplasmic Ca 2+ trigger a multitude of Ca 2+-dependent processes
in CNS neurons and many other cell types. The specificity, speed, and reliability of these …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …