Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
[HTML][HTML] Detection of viral infections by innate immunity
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …
innate immune system as they detect conserved viral pathogen-associated molecular …
[HTML][HTML] Phenotypic signatures of immune selection in HIV-1 reservoir cells
Abstract Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite
antiretroviral treatment, but may be vulnerable to host immune responses that could be …
antiretroviral treatment, but may be vulnerable to host immune responses that could be …
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques
A Dashti, S Sukkestad, AM Horner, M Neja, Z Siddiqi… - Nature Medicine, 2023 - nature.com
The main barrier to HIV cure is a persistent reservoir of latently infected CD4+ T cells
harboring replication-competent provirus that fuels rebound viremia upon antiretroviral …
harboring replication-competent provirus that fuels rebound viremia upon antiretroviral …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
CARD8 is an inflammasome sensor for HIV-1 protease activity
INTRODUCTION HIV-1 has high mutation rates and exists as mutant swarms within the host.
The adaptive immune system recognizes cognate epitopes based on amino acid sequences …
The adaptive immune system recognizes cognate epitopes based on amino acid sequences …
Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
CAR T cells for infection, autoimmunity and allotransplantation
Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells to
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells
M Dube, O Tastet, C Dufour, G Sannier, N Brassard… - Cell Host & Microbe, 2023 - cell.com
Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …
Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
JA White, FR Simonetti, S Beg… - Proceedings of the …, 2022 - National Acad Sciences
In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …