Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the
Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many …

Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and
bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in …

Purpose: Cancer-associated fibroblasts (CAF) are a major component of the colorectal
cancer tumor microenvironment. CAFs play an important role in tumor progression and …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Abstract Hereditary Hemorrhagic Telangiectasia (HHT), also known as Rendu-Osler
syndrome, is a genetic vascular disorder affecting 1 in 5000–8000 individuals worldwide …

Endoglin, a type-III accessory receptor for the Transforming Growth Factor (TGF)-β
superfamily pathway, is known for its crucial role during angiogenesis. Extensive work has …

Bone morphogenetic proteins (BMPs) are dimeric transforming growth factor ß (TGFß) family
cytokines that were first described in bone and cartilage formation but have since been …

Although bone morphogenetic proteins (BMPs) initially showed effective induction of ectopic
bone growth in muscle, it has since been determined that these proteins, as members of the …