The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Background Many common environmental chemicals are mammary gland carcinogens in
animal studies, activate relevant hormonal pathways, or enhance mammary gland …

Abstract Background Endocrine-disrupting compounds (EDCs) are ubiquitous substances
that are found in our everyday lives, including pesticides, plasticizers, pharmaceutical …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Background The long time from exposure to potentially harmful chemicals until breast
cancer occurrence poses challenges for designing etiologic studies and for implementing …

Exposure to toxic environmental chemicals during pregnancy and breastfeeding is
ubiquitous and is a threat to healthy human reproduction. There are tens of thousands of …

Pregnancy is a unique period when biological changes can increase sensitivity to chemical
exposures. Pregnant women are exposed to multiple environmental chemicals via air, food …

Founded in 1916, the Endocrine Society is the world's oldest, largest, and most active
organization devoted to research on hormones and the clinical practice of endocrinology …

In the United States, breast cancer is the most common invasive malignancy and the second
most common cause of death from cancer in women. Reproductive factors, estrogen, and …

Background Despite studies having consistently linked exposure to single-source polycyclic
aromatic hydrocarbons (PAHs) to breast cancer, it is unclear whether single sources or …