The immunology of Epstein-Barr virus–induced disease
Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …
Human immunity against EBV—lessons from the clinic
The mammalian immune system has evolved over many millennia to be best equipped to
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …
Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection
Epstein-Barr virus (EBV) is an enigma; on one hand, it infects and persists in latent form in
the vast majority of the global population, causing relatively benign disease in otherwise …
the vast majority of the global population, causing relatively benign disease in otherwise …
Herpesviruses: harmonious pathogens but relevant cofactors in other diseases?
Most vertebrates are infected with one or more herpesviruses and remain so for the rest of
their lives. The relationship of immunocompetent healthy host with herpesviruses may …
their lives. The relationship of immunocompetent healthy host with herpesviruses may …
XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus
FY Li, B Chaigne-Delalande, H Su… - Blood, The Journal …, 2014 - ashpublications.org
Epstein-Barr virus (EBV) is an oncogenic gammaherpesvirus that infects and persists in 95%
of adults worldwide and has the potential to cause fatal disease, especially lymphoma, in …
of adults worldwide and has the potential to cause fatal disease, especially lymphoma, in …
A human immunodeficiency syndrome caused by mutations in CARMIL2
T Schober, T Magg, M Laschinger, M Rohlfs… - Nature …, 2017 - nature.com
Human T-cell function is dependent on T-cell antigen receptor (TCR) and co-signalling as
evidenced by immunodeficiencies affecting TCR-dependent signalling pathways. Here, we …
evidenced by immunodeficiencies affecting TCR-dependent signalling pathways. Here, we …
Cellular immune controls over Epstein–Barr virus infection: new lessons from the clinic and the laboratory
Epstein–Barr virus (EBV), a human herpesvirus with potent B cell growth transforming ability,
induces multiple cellular immune responses in the infected host. How these host responses …
induces multiple cellular immune responses in the infected host. How these host responses …
Epstein–Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: a review
ML Marques-Piubelli, YI Salas, C Pachas… - Pathology, 2020 - Elsevier
In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas
associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive …
associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive …
Interleukin-2-inducible T-cell kinase (ITK) deficiency-clinical and molecular aspects
S Ghosh, K Bienemann, K Boztug… - Journal of Clinical …, 2014 - Springer
In patients with underlying immunodeficiency, Epstein-Barr virus (EBV) may lead to severe
immune dysregulation manifesting as fatal mononucleosis, lymphoma, lymphoproliferative …
immune dysregulation manifesting as fatal mononucleosis, lymphoma, lymphoproliferative …
Severe combined immunodeficiency disorders
IK Chinn, WT Shearer - Immunology and Allergy Clinics, 2015 - immunology.theclinics.com
Severe combined immunodeficiency disorders are characterized by a lack of protective T-, B-
, and sometimes NK-cell responses to infections. As a result, affected individuals are born …
, and sometimes NK-cell responses to infections. As a result, affected individuals are born …