Blood vessels affect the quality of life in many ways. They provide an essential nutritive
function during growth and repair of tissues but, on the other hand, can become affected by …

Substantial evidence exists which implicates the urokinase plasminogen activator system
[urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) …

The GPI‐anchored urokinase plasminogen activator receptor (uPAR) does not internalize
free urokinase (uPA) but readily internalizes and degrades uPA: serpin complexes in a …

In angiogenesis associated with tissue repair and disease, fibrin and inflammatory
mediators are often involved. We have used three-dimensional fibrin matrices to investigate …

Cancer cell invasion requires dissolution of basement membranes and other extracellular
protein structures, and for a long time it has been contemplated that this destruction is …

Mice homozygously deficient for the urokinase-type plasminogen activator (u-PA) receptor
(u-PAR-1-) were generated by homologous recombination in D3, embryonic stem cells. The …

The cellular prion protein (PrP C) is a glycolipid-anchored protein that is involved in the
pathogenesis of fatal spongiform encephalopathies. We have shown previously that, in …

Novel gene technologies have allowed us to manipulate the genetic balance of candidate
molecules in mice in a controllable manner. Homologous or site‐specific recombination in …

Optimal fibrin balance requires precisely controlled plasmin generation on the surface of
endothelial cells, which line the blood vessel wall. As a co-receptor for plasminogen and …

High levels of urokinase-type plasminogen activator (u-PA), of its inhibitor (plasminogen
activator inhibitor (PAI)-1), or of its receptor (u-PAR, CD87) are strong prognostic indicators …