Alzheimer's disease (AD) is the most common form of dementia affecting elderly people. AD
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

Introduction. Human neurodegenerative diseases increase progressively with age and
present a high social and economic burden. Growth hormone (GH) and insulin-like growth …

The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased
oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) …

Growth hormone (GH) and insulin-like growth factor (IGF)-1 regulate the development and
function of cells throughout the body. Several clinical diseases that result in a decline in …

Age-related impairment of neurovascular coupling (NVC; or “functional hyperemia”)
compromises moment-to-moment adjustment of regional cerebral blood flow to increased …

Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1
(GH/IGF-1) axis are associated with increased life-and healthspan across model organisms …

Aging is associated with a significant deficiency in circulating insulin-like growth factor-1
(IGF-1), which has an important role in the pathogenesis of age-related vascular cognitive …

Insulin-like growth factor (IGF)-1 is an important neurotrophic hormone. Deficiency of this
hormone has been reported to influence the genesis of cognitive impairment and dementia …