The physical and chemical factors that allow DNA to perform its functions in the cell have
been studied for several decades. Recent advances in the synthesis and manipulation of …

The field of DNA mismatch repair (MMR) has rapidly expanded after the discovery of the
MutHLS repair system in bacteria. By the mid 1990s yeast and human homologues to …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Attesting to the spectacular growth in the field of structural biology, the total number of
coordinate files deposited in the Protein Data Bank was rapidly approaching 30 000 entries …

O 6-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N′-
nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic …

The great Chinese strategist Sun Tsu wrote,“So it is said that if you know your enemies and
know yourself, you will fight without danger in battles.” 1 This quote was originally meant to …

In this review we describe the influence of modified nucleobases in order to understand the
changes they introduce in double and triple helix forming oligomers with the aim to study …

Alkylating agents such as N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) are known to
covalently link alkyl groups at the position 6 of guanines (O6MG) in DNA. O 6-alkylguanine …

The base pairs are the contributors to the sequence-dependent recognition of nucleic acids,
genetic information storage, and high fidelity of DNA polymerase replication. However, the …

The response of mammalian cells to S n 1 DNA methylators depends on functional MutSα
and MutLα. Cells deficient in either of these activities are resistant to the cytotoxic effects of …