Ageing is the greatest risk factor for the development of Parkinson's disease. However, the
current dogma holds that cellular mechanisms that are associated with ageing of midbrain …

Glutathione (GSH) was discovered in yeast cells in 1888. Studies of GSH in mammalian
cells before the 1980s focused exclusively on its function for the detoxication of xenobiotics …

Background Parkinson's disease (PD) is the most common movement disorder. While
neuronal deposition of α-synuclein serves as a pathological hallmark of PD and Dementia …

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …

Objective Dopaminergic neuronal death in Parkinson's disease (PD) is accompanied by
oxidative stress and preceded by glutathione depletion. The development of disease …

Parkinson disease (PD) used to be considered a nongenetic condition. However, the
identification of several autosomal dominant and recessive mutations linked to monogenic …

The biological underpinnings to the etiology and course of neurodegeneration in
Parkinson's disease are an area of extensive research that has yet to produce an early …

Astrocytes support neuronal antioxidant capacity by releasing glutathione, which is cleaved
to cysteine in brain extracellular space. Free cysteine is then taken up by neurons through …

Excess glutamatergic neurotransmission may contribute to excitotoxic loss of nigrostriatal
neurons in Parkinson's disease (PD). Here, we determined if increasing glutamate uptake …

Excitatory amino acid transporters (EAATs) are high-affinity Na+-dependent carriers of major
importance in maintaining glutamate homeostasis in the central nervous system. EAAT3, the …