The first prenatal screening test to be introduced was based on a single maternal serum
marker of neural tube defects. Since then various prenatal screening concepts have been …

Most brain abnormalities are present in the first trimester, but only a few are detected so
early in gestation. According to current recommendations for first‐trimester ultrasound, the …

Objectives To describe a new first‐trimester sonographic sign, the 'crash sign', associated
with fetal open spina bifida, and to evaluate its clinical usefulness in the first‐trimester …

Accurate and timely prenatal diagnosis of spina bifida (SB) is a major goal of modern
antenatal care. Prenatal screening for open SB should be first performed at the time of …

The author discusses the diagnosis of spina bifida at the 11-13-week scan by assessing
intracranial translucency and the posterior brain region. He examines the rationale for using …

The fetal central nervous system can already be examined in the first trimester of pregnancy.
Acrania, alobar holoprosencephaly, cephaloceles, and spina bifida can confidently be …

Objective To construct reference ranges for cisterna magna (CM) width at 11–13 weeks'
gestation in healthy fetuses and determine whether open spina bifida and posterior fossa …

Objective To evaluate the contribution of examination of specific anatomical features of the
fetal posterior brain on mid‐sagittal first‐trimester ultrasound examination to the early …

Objective To describe the sonographic appearance and position of the choroid plexus of the
fourth ventricle (4V‐CP) between 12 and 21 weeks' gestation in normal fetuses and in …

Objective To describe the sonographic appearance of fetal posterior fossa anatomy at 11–
14 weeks of pregnancy and to assess the outcome of fetuses with increased intracranial …