Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …

Inflammation is a risk factor for cancer development. Individuals with preleukemic TET2
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …

During myocardial infarction, infiltrated macrophages have pivotal roles in cardiac
remodeling and delayed M1 toward M2 macrophage phenotype transition is considered one …

Introduction Gastric cancer is a fatal malignancy with a rising incidence rate. Effective
methods for early diagnosis, monitoring metastasis, and prognosis are currently unavailable …

Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved
in the base excision repair (BER) pathway, which repairs oxidative base damage caused by …

Signal transducer and activator of transcription 3 (STAT3) controls many biological
processes including differentiation, survival, proliferation, and angiogenesis. In normal …

Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …

Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the …