The role of the anaphylatoxins in health and disease
A Klos, AJ Tenner, KO Johswich, RR Ager, ES Reis… - Molecular …, 2009 - Elsevier
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
Microglia and CNS interleukin-1: beyond immunological concepts
Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the
CNS have become almost synonymous with neuroinflammation. In numerous studies …
CNS have become almost synonymous with neuroinflammation. In numerous studies …
Retinal microglia: Functions and diseases
W Fan, W Huang, J Chen, N Li, L Mao, S Hou - Immunology, 2022 - Wiley Online Library
Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …
contributions to the maintenance of normal homeostasis and immune surveillance of these …
Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity
AD Kraft, GJ Harry - International journal of environmental research and …, 2011 - mdpi.com
Microglia are resident cells of the brain involved in regulatory processes critical for
development, maintenance of the neural environment, injury and repair. They belong to the …
development, maintenance of the neural environment, injury and repair. They belong to the …
Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in …
C Hock, K Heese, C Hulette, C Rosenberg… - Archives of …, 2000 - jamanetwork.com
Background Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
neurotrophin 3 (NT-3), and neurotrophin 4/5 (NT-4/5) are members of the neurotrophin gene …
neurotrophin 3 (NT-3), and neurotrophin 4/5 (NT-4/5) are members of the neurotrophin gene …
Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and-2
C Knott, G Stern, GP Wilkin - Molecular and Cellular Neuroscience, 2000 - Elsevier
Degeneration of dopaminergic neurons and focal gliosis are pathological hallmarks of
Parkinson's disease and although the brain is described as immune-privileged focal …
Parkinson's disease and although the brain is described as immune-privileged focal …
Sepsis: network pathophysiology and implications for early diagnosis
J Arora, AA Mendelson… - American Journal of …, 2023 - journals.physiology.org
Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …
Degenerative and regenerative mechanisms governing spinal cord injury
C Profyris, SS Cheema, DW Zang, MF Azari… - Neurobiology of …, 2004 - Elsevier
Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …
accepted treatment. The functional decline following SCI is contributed to both direct …
The role of the complement system in traumatic brain injury: a review
A Hammad, L Westacott, M Zaben - Journal of neuroinflammation, 2018 - Springer
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western
world. While the initial injury sustained results in damage, it is the subsequent secondary …
world. While the initial injury sustained results in damage, it is the subsequent secondary …
Neurotrophic factors in Alzheimer's and Parkinson's disease brain
GJ Siegel, NB Chauhan - Brain Research Reviews, 2000 - Elsevier
The biomedical literature on the subject of neurotrophic growth factors has expanded
prodigiously. This essay reviews neurotrophic factors (NTF) and their receptors in …
prodigiously. This essay reviews neurotrophic factors (NTF) and their receptors in …