Translational applications of hydrogels

S Correa, AK Grosskopf, H Lopez Hernandez… - Chemical …, 2021 - ACS Publications
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Synthetic amorphous silica nanoparticles: toxicity, biomedical and environmental implications

JG Croissant, KS Butler, JI Zink, CJ Brinker - Nature Reviews Materials, 2020 - nature.com
Natural silica and silicates are predominantly crystalline and constitute the most abundant
components of the Earth's crust. Man-made silica is typically amorphous and manufactured …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

N Boehnke, JP Straehla, HC Safford, M Kocak… - Science, 2022 - science.org
To accelerate the translation of cancer nanomedicine, we used an integrated genomic
approach to improve our understanding of the cellular processes that govern nanoparticle …

Layer-by-layer biomaterials for drug delivery

D Alkekhia, PT Hammond… - Annual review of …, 2020 - annualreviews.org
Controlled drug delivery formulations have revolutionized treatments for a range of health
conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as …

Multifunctional mesoporous silica nanoparticles for biomedical applications

B Xu, S Li, R Shi, H Liu - Signal Transduction and Targeted Therapy, 2023 - nature.com
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of
nanotechnology applied in the biomedical field, due to their easily tunable structure and …

A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles

JP Straehla, C Hajal, HC Safford… - Proceedings of the …, 2022 - National Acad Sciences
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

Polymer-modified liposomes for drug delivery: from fundamentals to applications

Y Cao, X Dong, X Chen - Pharmaceutics, 2022 - mdpi.com
Liposomes are highly advantageous platforms for drug delivery. To improve the colloidal
stability and avoid rapid uptake by the mononuclear phagocytic system of conventional …

Nanoarchitectonics beyond perfect order–not quite perfect but quite useful

L Cao, Y Huang, B Parakhonskiy, AG Skirtach - Nanoscale, 2022 - pubs.rsc.org
Nanoarchitectonics, like architectonics, allows the design and building of structures, but at
the nanoscale. Unlike those in architectonics, and even macro-, micro-, and atomic-scale …

Different strategies for organic nanoparticle preparation in biomedicine

F Fang, M Li, J Zhang, CS Lee - ACS Materials Letters, 2020 - ACS Publications
Organic nanoparticles with intriguing features have attracted widespread attention for
various biomedical applications, such as disease diagnosis, drug delivery, bioimaging, and …