A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has
homologs in nearly all organisms. Because of its connection to parkinsonism and cancer …

Abstract Both homozygous (L166P, M26I, deletion) and heterozygous mutations (D149A,
A104T) in the DJ-1 gene have been identified in Parkinson's disease (PD) patients. The …

Mutations in the PARK7/DJ-1 gene are rare causes of autosomal-recessive hereditary
Parkinson's disease. Loss-of-function mutations lead to the characteristic selective …

The formation of cysteine-sulfinic acid has recently become appreciated as a modification
that links protein function to cellular oxidative status. Human DJ-1, a protein associated with …

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the
loss of neurons in the substantia nigra pars compacta and the presence of Lewy bodies in …

Neurodegenerative diseases (NDs) are one of the major health threats to human
characterized by selective and progressive neuronal loss. The mechanisms of NDs are still …

Parkinson's disease (PD) is a major neurodegenerative condition with several rare
Mendelian forms. Oxidative stress and mitochondrial function have been implicated in the …

DJ-1 is a redox-sensitive protein with several putative functions important in mitochondrial
physiology, protein transcription, proteasome regulation, and chaperone activity. High levels …

By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a
significant proportion (50-70%) of the cells in the substantia nigra (SN) has already been …