The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

At fifteen different genomic locations, the expansion of a CAG/CTG repeat causes a
neurodegenerative or neuromuscular disease, the most common being Huntington's …

Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging
chemotherapeutic agents. To explore genetic resistance mechanisms, we performed …

Secondary structure-forming DNA sequences such as CAG repeats interfere with replication
and repair, provoking fork stalling, chromosome fragility, and recombination. In budding …

DNA repair must take place in the context of chromatin, and chromatin modifications and
DNA repair are intimately linked. The study of double-strand break repair has revealed …

DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic
consequences for genome stability if not properly repaired. DSBs can be repaired by either …

Repetitive sequences throughout the genome are a major source of endogenous DNA
damage, due to the propensity of many of them to form alternative non-B DNA structures that …

Many microsatellite DNA sequences are able to form non-B form DNA secondary structures,
such as hairpin loops, cruciforms, triplex DNA or G-quadruplexes. These DNA structures can …

CAG/CTG repeat expansions cause over 13 neurological diseases that remain without a
cure. Because longer tracts cause more severe phenotypes, contracting them may provide a …

Accurate completion of genome duplication is threatened by multiple factors that hamper the
advance and stability of the replication forks. Cells need to tolerate many of these blocking …