The structure of the nuclear pore complex (an update)
The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
M Nassal - Gut, 2015 - gut.bmj.com
At least 250 million people worldwide are chronically infected with HBV, a small
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …
[PDF][PDF] Present and future therapies of hepatitis B: from discovery to cure
Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million
people worldwide. While treatment for HBV has improved, HBV patients often require …
people worldwide. While treatment for HBV has improved, HBV patients often require …
Core protein: A pleiotropic keystone in the HBV lifecycle
Abstract Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading
frames. We argue that the simplicity of the virion correlates with a complexity of functions for …
frames. We argue that the simplicity of the virion correlates with a complexity of functions for …
Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure
MB Zeisel, J Lucifora, WS Mason, C Sureau, J Beck… - Gut, 2015 - gut.bmj.com
HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …
[HTML][HTML] Hepatitis B virus molecular biology and pathogenesis
RJ Lamontagne, S Bagga, MJ Bouchard - Hepatoma research, 2016 - ncbi.nlm.nih.gov
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
Pathogenicity and virulence of Hepatitis B virus
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …
an estimated 296 million people in the world that are chronically infected by this virus, and …
Attacking hepatitis B virus cccDNA–The holy grail to hepatitis B cure
J Lucifora, U Protzer - Journal of hepatology, 2016 - Elsevier
HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of
infected cells. As the central transcription template, the cccDNA minichromosome is a key …
infected cells. As the central transcription template, the cccDNA minichromosome is a key …
Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity
KA Matreyek, SS Yücel, X Li, A Engelman - PLoS pathogens, 2013 - journals.plos.org
Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide
crucial functions for lentiviral nuclear entry and integration. We previously showed that the …
crucial functions for lentiviral nuclear entry and integration. We previously showed that the …
Virus entry at a glance
Y Yamauchi, A Helenius - Journal of cell science, 2013 - journals.biologists.com
The goal of a virus particle is to transport its genome in a replication-competent form from an
infected cell to an uninfected cell. To enter a new host cell, the majority of viruses take …
infected cell to an uninfected cell. To enter a new host cell, the majority of viruses take …