Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

A growing number of studies have demonstrated the role of post-translational modifications
of proteins, particularly acetylation, in human diseases including neurodegenerative and …

The mammalian sirtuin family has attracted tremendous attention over the past few years as
stress adaptors and post-translational modifier. They have involved in diverse cellular …

Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have much more functions and to be much more abundant in living organisms …