Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …

Background: Mutations in LMNA are variably expressed and may cause cardiomyopathy,
atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA) …

Mechanical forces are known to influence cellular processes with consequences at the
cellular and physiological level. The cell nucleus is the largest and stiffest organelle, and it is …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy.
Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure …

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines
expressed in many different cell types including skeletal muscle. Members of this …

Diabetes and obesity are both associated with lipotoxic cardiomyopathy exclusive of
coronary artery disease and hypertension. Lipotoxicities have become a public health …

Mutations in the lamin A/C gene (LMNA), which encodes A-type lamins, cause a diverse
range of diseases collectively called laminopathies, the most common of which is dilated …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …