The positron-emitting radionuclide gallium-68 has become increasingly utilised in both
preclinical and clinical settings with positron emission tomography (PET). The synthesis of …

Multimeric ligands consisting of multiple pharmacophores connected to a single backbone
have been widely investigated for diagnostic and therapeutic applications. In this review, we …

The HBED chelator is used to stabilize small and hard metal ions such as Fe3+, Ti4+, Ga3+
and Al3+ in both medicine and industry. While the coordination of hexadentate HBED4− is …

Tyrosine Kinases are enzymes that catalyse the phosphorylation of the tyrosine residues of
their substrates and activate downstream pathways involved in cellular proliferation. Their …

Overexpression of the epidermal growth factor receptor (EGFR, erbB1) has been observed
in a wide range of solid tumors and has frequently been associated with poor prognosis. As …

Epidermal growth factor receptors (EGFR) of tyrosine kinase (TK) have shown high
expression levels in most cancers and are considered a promising target for cancer …

In radiopharmaceutical syntheses, maleimide is commonly used for linking thiol-bearing
bioactive molecules to metal–complexing ligands (chelators). However, due to instability of …

Bis-3-(4-chlorophenyl)-2, 3-dihydroquinazolin-4 (1H)-on-2-thioxopropane (C), a quinazoline
derivative was synthesized and well-characterized in order to evaluate its potential to act as …

Pretargeted PET imaging allows the use of radiotracers labeled with short-living PET
radionuclides for tracing drugs with slow pharmacokinetics. Recently, especially methods …

This review intends to summarize the structures of an extensive number of symmetrical-
dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility …