Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …

Abstract Significance: Peroxiredoxins (Prxs) are thiol peroxidases with multiple functions in
the antioxidant defense and redox signaling network of the cell. Our progressing …

Cys is much different from other common amino acids in proteins. Being one of the least
abundant residues, Cys is often observed in functional sites in proteins. This residue is …

Protein thiol reactivity generally involves the nucleophilic attack of the thiolate on an
electrophile. A low p K a means higher availability of the thiolate at neutral pH but often a …

Protein sulfenic acid formation has long been regarded as unwanted damage caused by
reactive oxygen species (ROS). However, over the past 10 years, accumulating evidence …

The oxidation of biothiols participates not only in the defense against oxidative damage but
also in enzymatic catalytic mechanisms and signal transduction processes. Thiols are …

Life on Earth evolved in the presence of hydrogen peroxide, and other peroxides also
emerged before and with the rise of aerobic metabolism. They were considered only as toxic …

Abstract The PeroxiBase (http://peroxibase. toulouse. inra. fr/) is a specialized database
devoted to peroxidases' families, which are major actors of stress responses. In addition to …