Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
Chalcone: a promising bioactive scaffold in medicinal chemistry
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease
Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …
The Keap1/Nrf2-ARE pathway as a pharmacological target for chalcones
Chalcones have shown a broad spectrum of biological activities with clinical potential
against various diseases. The biological activities are mainly attributed to the presence in …
against various diseases. The biological activities are mainly attributed to the presence in …
Esculetin as a bifunctional antioxidant prevents and counteracts the oxidative stress and neuronal death induced by amyloid protein in SH-SY5Y cells
Oxidative stress (OS) appears to be an important determinant during the different stages of
progression of Alzheimer's Disease (AD). In particular, impaired antioxidant defense …
progression of Alzheimer's Disease (AD). In particular, impaired antioxidant defense …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …
Design and synthesis of H2S-donor hybrids: a new treatment for Alzheimer's disease?
Hydrogen sulphide (H 2 S) is an endogenous gasotransmitter, largely known as a
pleiotropic mediator endowed with antioxidant, anti-inflammatory, pro-autophagic, and …
pleiotropic mediator endowed with antioxidant, anti-inflammatory, pro-autophagic, and …
Novel curcumin-diethyl fumarate hybrid as a dualistic GSK-3β inhibitor/Nrf2 inducer for the treatment of Parkinson's disease
RMC Di Martino, L Pruccoli, A Bisi… - ACS Chemical …, 2020 - ACS Publications
Common copathogenic factors, including oxidative stress and neuroinflammation, are found
to play a vital role in the development of neurodegenerative disorders, including Alzheimer's …
to play a vital role in the development of neurodegenerative disorders, including Alzheimer's …
Binding studies of potential amyloid-β inhibiting chalcone derivative with bovine serum albumin
S Daksh, C Gond, N Kumar, L Kaur, H Ojha… - … Acta Part A: Molecular …, 2024 - Elsevier
Abstract Chalcones (α-phenyl-β-benzoylethylene) and their natural-source derivatives have
been investigated for their remarkable biological activities, like neuroprotective, anti …
been investigated for their remarkable biological activities, like neuroprotective, anti …
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
S Montanari, AM Mahmoud, L Pruccoli… - European Journal of …, 2019 - Elsevier
To address the multifactorial nature of Alzheimer's Disease (AD), a multi-target-directed
ligand approach was herein developed. As a follow-up of our previous studies, a small …
ligand approach was herein developed. As a follow-up of our previous studies, a small …