The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of
a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

In light of the worldwide epidemic of obesity, and in recognition of hypertension as a major
factor in the cardiovascular morbidity and mortality associated with obesity, The Obesity …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Obesity is a growing global health concern, with a rapid increase being observed in morbid
obesity. Obesity is associated with an increased cardiovascular risk and earlier onset of …

Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in
the regulation of numerous vital biological functions, contributes to the development and …

In obese patients with type 2 diabetes, insulin delivery to and insulin-dependent glucose
uptake by skeletal muscle are delayed and impaired. The mechanisms underlying the delay …