Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
The number and diversity of known CRISPR–Cas systems have substantially increased in
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …
History of CRISPR-Cas from encounter with a mysterious repeated sequence to genome editing technology
Y Ishino, M Krupovic, P Forterre - Journal of bacteriology, 2018 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are well-
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …
[HTML][HTML] iPHoP: An integrated machine learning framework to maximize host prediction for metagenome-derived viruses of archaea and bacteria
The extraordinary diversity of viruses infecting bacteria and archaea is now primarily studied
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
[HTML][HTML] Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome
Bacteriophages have important roles in the ecology of the human gut microbiome but are
under-represented in reference databases. To address this problem, we assembled the …
under-represented in reference databases. To address this problem, we assembled the …
Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations
Candidate phyla radiation (CPR) bacteria and DPANN (an acronym of the names of the first
included phyla) archaea are massive radiations of organisms that are widely distributed …
included phyla) archaea are massive radiations of organisms that are widely distributed …
New CRISPR–Cas systems from uncultivated microbes
D Burstein, LB Harrington, SC Strutt, AJ Probst… - Nature, 2017 - nature.com
CRISPR–Cas systems provide microbes with adaptive immunity by employing short DNA
sequences, termed spacers, that guide Cas proteins to cleave foreign DNA,. Class 2 …
sequences, termed spacers, that guide Cas proteins to cleave foreign DNA,. Class 2 …
[HTML][HTML] Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats
Many microbes in nature reside in dense, metabolically interdependent communities. We
investigated the nature and extent of microbe-virus interactions in relation to microbial …
investigated the nature and extent of microbe-virus interactions in relation to microbial …
Anti-CRISPR: discovery, mechanism and function
CRISPR–Cas adaptive immune systems are widespread among bacteria and archaea.
Recent studies have shown that these systems have minimal long-term evolutionary effects …
Recent studies have shown that these systems have minimal long-term evolutionary effects …
[HTML][HTML] Alterations in enteric virome are associated with colorectal cancer and survival outcomes
Background & Aims Patients with colorectal cancer (CRC) have a different gut microbiome
signature than individuals without CRC. Little is known about the viral component of CRC …
signature than individuals without CRC. Little is known about the viral component of CRC …
[HTML][HTML] Bacteriophages and bacterial plant diseases
Losses in crop yields due to disease need to be reduced in order to meet increasing global
food demands associated with growth in the human population. There is a well-recognized …
food demands associated with growth in the human population. There is a well-recognized …