Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

C Guo, D Guo, L Fang, T Sang, J Wu, C Guo… - Carbohydrate …, 2021 - Elsevier
This study investigated the effects of water-soluble polysaccharide extracted from the
sporoderm-removed spores of Ganoderma lucidum (GLP) against AOM/DSS-induced …

Altered insulin signaling in Alzheimer's disease brain–special emphasis on PI3K-Akt pathway

S Gabbouj, S Ryhänen, M Marttinen… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective …

Brown algae carbohydrates: Structures, pharmaceutical properties, and research challenges

Y Li, Y Zheng, Y Zhang, Y Yang, P Wang, B Imre… - Marine drugs, 2021 - mdpi.com
Brown algae (Phaeophyceae) have been consumed by humans for hundreds of years.
Current studies have shown that brown algae are rich sources of bioactive compounds with …

[HTML][HTML] The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?

E Razani, A Pourbagheri-Sigaroodi… - Cell Stress and …, 2021 - Elsevier
Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

Alginate oligosaccharides: Production, biological activities, and potential applications

J Liu, S Yang, X Li, Q Yan… - … Reviews in Food …, 2019 - Wiley Online Library
Alginate, a group of polyuronic saccharides, has been widely used in both pharmaceutical
and food industries due to its unique physicochemical properties as well as beneficial health …

Attenuation of lipopolysaccharide-induced acute lung injury by hispolon in mice, through regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 pathways, and …

CY Huang, JS Deng, WC Huang, WP Jiang, GJ Huang - Nutrients, 2020 - mdpi.com
The anti-inflammatory effect of hispolon has identified it as one of the most important
compounds from Sanghuangporus sanghuang. The research objectives were to study this …

[HTML][HTML] Potential applications of alginate oligosaccharides for biomedicine–a mini review

M Wang, L Chen, Z Zhang - Carbohydrate Polymers, 2021 - Elsevier
Extensive research on marine algae, especially on their health-promoting properties, has
been conducted. Various ingredients with potential biomedical applications have been …

Advances in research on the bioactivity of alginate oligosaccharides

M Xing, Q Cao, Y Wang, H Xiao, J Zhao, Q Zhang, A Ji… - Marine drugs, 2020 - mdpi.com
Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate
oligosaccharide (AOS) is a degradation product of alginate, which has received increasing …