Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment‐related aspects of apathy from depression in …

KL Lanctôt, Z Ismail, KK Bawa… - … journal of geriatric …, 2023 - Wiley Online Library
Objectives This narrative review describes the clinical features of apathy and depression in
individuals with neurocognitive disorders (NCDs), with the goal of differentiating the two …

Protein misfolding and aggregation in the brain: common pathogenetic pathways in neurodegenerative and mental disorders

A Ochneva, Y Zorkina, O Abramova, O Pavlova… - International journal of …, 2022 - mdpi.com
Mental disorders represent common brain diseases characterized by substantial
impairments of social and cognitive functions. The neurobiological causes and mechanisms …

Late-life depression is associated with reduced cortical amyloid burden: Findings from the Alzheimer's Disease Neuroimaging Initiative Depression Project

RS Mackin, PS Insel, S Landau, D Bickford, R Morin… - Biological …, 2021 - Elsevier
Background We evaluated the role of cortical amyloid deposition as a factor contributing to
memory dysfunction and increased risk of dementia associated with late-life depression …

A randomized double-blind placebo-controlled trial of combined escitalopram and memantine for older adults with major depression and subjective memory …

H Lavretsky, KT Laird, B Krause-Sorio… - The American Journal of …, 2020 - Elsevier
Objective Geriatric depression is difficult to treat and frequently accompanied by cognitive
complaints that increase risk for dementia. New treatment strategies targeting both …

A transnosographic approach of negative symptoms pathophysiology in schizophrenia and depressive disorders

SB Guessoum, Y Le Strat, C Dubertret… - Progress in Neuro …, 2020 - Elsevier
Abstract Background: Negative Symptoms (blunted affect, alogia, anhedonia, avolition and
asociality) are observed in schizophrenia but also in depressive disorders. Objective: To …

A complex relationship between suicide, dementia, and amyloid: a narrative review

I Conejero, S Navucet, J Keller, E Olié… - Frontiers in …, 2018 - frontiersin.org
Background: Suicide rates are high among older adults and many conditions have been
related to suicide in this population: chronic illnesses, physical disabilities, cancer, social …

Regional tau correlates of instrumental activities of daily living and apathy in mild cognitive impairment and Alzheimer's disease dementia

GA Marshall, JR Gatchel, NJ Donovan… - Journal of …, 2019 - content.iospress.com
Background: Instrumental activities of daily living (IADL) impairment and apathy occur in
early-stage Alzheimer's disease (AD) and are associated with regional atrophy and …

Affective computing for late-life mood and cognitive disorders

E Smith, EA Storch, I Vahia, STC Wong… - Frontiers in …, 2021 - frontiersin.org
Affective computing (also referred to as artificial emotion intelligence or emotion AI) is the
study and development of systems and devices that can recognize, interpret, process, and …

Pharmacologic approaches for the management of apathy in neurodegenerative disorders

A Bogdan, V Manera, A Koenig, R David - Frontiers in pharmacology, 2020 - frontiersin.org
Apathy is one of the most frequent behavioral disturbances in many neurodegenerative
disorders and is known to have a negative impact on the disease progression, particularly in …

Neuroanatomical abnormalities in older depressed adults with apathy: a systematic review

MA Pimontel, D Kanellopoulos… - Journal of geriatric …, 2020 - journals.sagepub.com
Objective: Apathy is a common phenomenon in late-life depression and is associated with
poor outcomes. Apathy is often unrecognized in older depressed adults, and efficacious …