The value of the β-lactam antibiotics for the control of bacterial infection has eroded with
time. Three Gram-positive human pathogens that were once routinely susceptible to β …

Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …

Penicillin binding proteins (PBPs) have been extensively studied due to their importance to
the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used …

Essential genes encode the processes that are necessary for life. Until recently, commonly
applied binary classifications left no space between essential and non-essential genes. In …

Commercial carbapenem antibiotics are being used to treat multidrug resistant (MDR) and
extensively drug resistant (XDR) tuberculosis. Like other β-lactams, carbapenems are …

The cell wall envelope of mycobacteria is structurally distinct from that of both Gram‐positive
and Gram‐negative bacteria. In Mycobacterium tuberculosis, this cell wall has unique …

Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), is one of the
leading cause of death by an infectious diseases. The biosynthesis of the mycobacterial cell …

Mycobacterium abscessus causes serious infections that often require over 18 months of
antibiotic combination therapy. There is no standard regimen for the treatment of M …

Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb),
infects 10 million people a year. An estimated 25% of humans harbor latent TB infections, an …

Beta-lactams have been excluded from tuberculosis therapy due to the intrinsic resistance of
Mycobacterium tuberculosis (Mtb) to this antibiotic class, usually attributed to a potent beta …