Plasmin, one of the most potent and reactive serine proteases, is involved in various
physiological processes, including embryo development, thrombolysis, wound healing and …

Growing evidence suggests that plasmin is involved in a number of physiological processes
in addition to its key role in fibrin cleavage. Plasmin inhibition is critical in preventing …

Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin.
Circulating plasminogen, which comprises a Pan-apple (PAp) domain, five kringle domains …

The role and the mechanisms by which β1 integrins regulate the survival and
chemoresistance of T cell acute lymphoblastic leukemia (T-ALL) still are poorly addressed …

Tissue regeneration during wound healing or cancer growth and progression depends on
the establishment of a cellular microenvironment. Mesenchymal stem cells (MSC) are part of …

Hyperfibrinolytic situations can lead to life-threatening bleeding, especially during cardiac
surgery. The approved antifibrinolytic agents such as tranexamic acid, ε-aminocaproic acid …

The zymogen protease plasminogen and its active form plasmin perform key roles in blood
clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation …

The systemic inflammatory response observed during acute graft-versus-host disease
(aGVHD) is driven by proinflammatory cytokines, a 'cytokine storm'. The function of plasmin …

The tumor microenvironment is recognized as a key factor in the multiple stages of cancer
progression, mediating local resistance, immune-escape and metastasis. Cancer growth …

Background: Matrix metalloproteinase-2 (gelatinase-A, Mr 72,000 type IV collagenase, MMP-
2) and-9 (gelatinase-B, Mr 92,000 type IV collagenase, MMP-9) are key molecules that play …