Toxoplasma Effectors Targeting Host Signaling and Transcription

MA Hakimi, P Olias, LD Sibley - Clinical microbiology reviews, 2017 - Am Soc Microbiol
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

The interplay between toxoplasmosis and host miRNAs: Mechanisms and consequences

AS Doghish, MA Ali, MA Elrebehy, HH Mohamed… - … -Research and Practice, 2023 - Elsevier
Toxoplasmosis is one of the highly prevalent zoonotic diseases worldwide caused by the
parasite Toxoplasma gondii (T. gondii). The infection with T. gondii could pass unidentified …

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection

KJ Pittman, MT Aliota, LJ Knoll - BMC genomics, 2014 - Springer
Background The obligate intracellular parasite Toxoplasma gondii establishes a life-long
chronic infection within any warm-blooded host. After ingestion of an encysted parasite, T …

The clinical application of microRNAs in infectious disease

RE Drury, D O'Connor, AJ Pollard - Frontiers in immunology, 2017 - frontiersin.org
MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that
posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging …

MicroRNAs: biological regulators in pathogen–host interactions

SM Acuna, LM Floeter-Winter, SM Muxel - Cells, 2020 - mdpi.com
An inflammatory response is essential for combating invading pathogens. Several effector
components, as well as immune cell populations, are involved in mounting an immune …

Pathogenic infection in male mice changes sperm small RNA profiles and transgenerationally alters offspring behavior

S Tyebji, AJ Hannan, CJ Tonkin - Cell Reports, 2020 - cell.com
Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon
changes in experience and environment. Immune activation due to infection can also …

Gut microbes and host behavior: the forgotten members of the gut-microbiome

A Weiner, S Turjeman, O Koren - Neuropharmacology, 2023 - Elsevier
The gut microbiota refers to an entire population of microorganisms that colonize the gut.
This community includes viruses, prokaryotes (bacteria and archaea), and eukaryotes (fungi …

Toxoplasma gondii: CD8 T Cells Cry for CD4 Help

IA Khan, SJ Hwang, M Moretto - Frontiers in cellular and infection …, 2019 - frontiersin.org
Toxoplasma gondii, an apicomplexan parasite, is a pathogenic protozoan that can infect the
central nervous system. In pregnant women, infection can result in congenital problems of …

Human microRNAs in host–parasite interaction: a review

S Paul, LM Ruiz-Manriquez, FI Serrano-Cano… - 3 Biotech, 2020 - Springer
MicroRNAs (miRNAs) are a group of small noncoding RNA molecules with significant
capacity to regulate the gene expression at the post-transcriptional level in a sequence …