Inhibitory stabilization and cortical computation
Neuronal networks with strong recurrent connectivity provide the brain with a powerful
means to perform complex computational tasks. However, high-gain excitatory networks are …
means to perform complex computational tasks. However, high-gain excitatory networks are …
[HTML][HTML] Regulation of circuit organization and function through inhibitory synaptic plasticity
Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
An increase of inhibition drives the developmental decorrelation of neural activity
Throughout development, the brain transits from early highly synchronous activity patterns to
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying …
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying …
[HTML][HTML] How many neurons are sufficient for perception of cortical activity?
Many theories of brain function propose that activity in sparse subsets of neurons underlies
perception and action. To place a lower bound on the amount of neural activity that can be …
perception and action. To place a lower bound on the amount of neural activity that can be …
[HTML][HTML] Spatiotemporal constraints on optogenetic inactivation in cortical circuits
Optogenetics allows manipulations of genetically and spatially defined neuronal populations
with excellent temporal control. However, neurons are coupled with other neurons over …
with excellent temporal control. However, neurons are coupled with other neurons over …
[HTML][HTML] A disinhibitory circuit for contextual modulation in primary visual cortex
Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex,
responses to a stimulus are modulated by context, the visual scene surrounding the …
responses to a stimulus are modulated by context, the visual scene surrounding the …
[HTML][HTML] VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli
DJ Millman, GK Ocker, S Caldejon, I Kato, JD Larkin… - Elife, 2020 - elifesciences.org
Vasoactive intestinal peptide-expressing (VIP) interneurons in the cortex regulate feedback
inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) …
inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) …
[HTML][HTML] What is the dynamical regime of cerebral cortex?
Y Ahmadian, KD Miller - Neuron, 2021 - cell.com
Many studies have shown that the excitation and inhibition received by cortical neurons
remain roughly balanced across many conditions. A key question for understanding the …
remain roughly balanced across many conditions. A key question for understanding the …
[HTML][HTML] Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
Across a range of motor and cognitive tasks, cortical activity can be accurately described by
low-dimensional dynamics unfolding from specific initial conditions on every trial. These" …
low-dimensional dynamics unfolding from specific initial conditions on every trial. These" …
[HTML][HTML] Transcranial electrical stimulation: How can a simple conductor orchestrate complex brain activity?
Transcranial electrical stimulation (tES) is one of the oldest and yet least understood forms of
brain stimulation. The idea that a weak electrical stimulus, applied outside the head, can …
brain stimulation. The idea that a weak electrical stimulus, applied outside the head, can …