Chemical genetic interaction profiling reveals determinants of intrinsic antibiotic resistance in Mycobacterium tuberculosis
W Xu, MA DeJesus, N Rücker… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Chemotherapy for tuberculosis (TB) is lengthy and could benefit from synergistic adjuvant
therapeutics that enhance current and novel drug regimens. To identify genetic determinants …
therapeutics that enhance current and novel drug regimens. To identify genetic determinants …
Combinations of β-lactam antibiotics currently in clinical trials are efficacious in a DHP-I-deficient mouse model of tuberculosis infection
J Rullas, N Dhar, JD McKinney… - Antimicrobial agents …, 2015 - Am Soc Microbiol
We report here a dehydropeptidase-deficient murine model of tuberculosis (TB) infection
that is able to partially uncover the efficacy of marketed broad-spectrum β-lactam antibiotics …
that is able to partially uncover the efficacy of marketed broad-spectrum β-lactam antibiotics …
Mutation in an unannotated protein confers carbapenem resistance in Mycobacterium tuberculosis
ABSTRACT β-Lactams are the most widely used antibacterials. Among β-lactams,
carbapenems are considered the last line of defense against recalcitrant infections. As …
carbapenems are considered the last line of defense against recalcitrant infections. As …
Revisiting the β-lactams for tuberculosis therapy with a compound-compound synthetic lethality approach
S Xiao, H Guo, WS Weiner, C Maddox… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The suboptimal effectiveness of β-lactam antibiotics against Mycobacterium tuberculosis has
hindered the utility of this compound class for tuberculosis treatment. However, the results of …
hindered the utility of this compound class for tuberculosis treatment. However, the results of …
Identification of mycobacterial genes involved in antibiotic sensitivity: implications for the treatment of tuberculosis with β-lactam-containing regimens
G Viswanathan, S Yadav… - Antimicrobial Agents and …, 2017 - Am Soc Microbiol
In a Mycobacterium smegmatis mutant library screen, transposon mutants with insertions in
fhaA, dprE2, rpsT, and parA displayed hypersusceptibility to antibiotics, including the β …
fhaA, dprE2, rpsT, and parA displayed hypersusceptibility to antibiotics, including the β …
Collateral sensitivity to β-lactam drugs in drug-resistant tuberculosis is driven by the transcriptional wiring of BlaI operon genes
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another,
known as “collateral sensitivity.” This underexplored phenomenon opens new therapeutic …
known as “collateral sensitivity.” This underexplored phenomenon opens new therapeutic …