Structural and numerical alterations of chromosome 21 are extremely common in
hematological malignancies. While the functional impact of chimeric transcripts from fused …

We find that RAS is mutated in common and rare pediatric malignancies and that oncogenic
RAS confers a functional dependency in these cancers. Many strategies for targeting RAS …

Chromosomal rearrangements and specific aneuploidy patterns are initiating events and
define subgroups in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here we …

The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

Activating point mutations of the RAS gene act as driver mutations for a subset of precursor‐
B cell acute lymphoblastic leukaemias (pre‐B ALL) and represent an ambitious target for …

Myc is a pivotal protooncogenic transcription factor that contributes to the development of
almost all Burkitt's lymphomas and about one-third of diffuse large B-cell lymphomas. How B …

The RB1 tumor suppressor is recurrently mutated in a variety of cancers including
retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers …

Acute lymphoblastic leukemia (ALL) is characterized by the presence of chromosomal
changes, including numerical changes, translocations, and deletions, which are often …

Pancreatic cancer is often treatment-resistant, with the emerging standard of care,
gemcitabine, affording only a few months of incrementally-deteriorating survival. Reflecting …

An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic
leukemia/lymphoma with short latency and high penetrance | Leukemia Skip to main content …