Natural products from Photorhabdus and Xenorhabdus: mechanisms and impacts

H Cimen, M Touray, SH Gulsen, S Hazir - Applied Microbiology and …, 2022 - Springer
Insects and fungal pathogens pose constant problems to public health and agriculture,
especially in resource-limited parts of the world; and the use of chemical pesticides …

Photorhabdus and a Host of Hosts

NR Waterfield, T Ciche, D Clarke - Annual review of …, 2009 - annualreviews.org
Photorhabdus is a member of the family Enterobacteriaceae that lives in a mutualistic
association with a Heterorhabditis nematode worm. The nematode worm burrows into insect …

Insecticidal toxins from Photorhabdus bacteria and their potential use in agriculture

A Dowling, NR Waterfield - Toxicon, 2007 - Elsevier
Most of the insecticidal toxins used in agriculture come from a single bacterium Bacillus
thuringiensis or 'Bt'. Here we review our work on the array of toxins produced by …

Molecular analysis of a novel gene cluster encoding an insect toxin in plant‐associated strains of Pseudomonas fluorescens

M Péchy‐Tarr, DJ Bruck, M Maurhofer… - Environmental …, 2008 - Wiley Online Library
Pseudomonas fluorescens CHA0 and the related strain Pf‐5 are well‐characterized
representatives of rhizosphere bacteria that have the capacity to protect crop plants from …

Photorhabdus Virulence Cassettes Confer Injectable Insecticidal Activity against the Wax Moth

G Yang, AJ Dowling, U Gerike… - Journal of …, 2006 - Am Soc Microbiol
Two recently sequenced genomes of the insect-pathogenic bacterium Photorhabdus and a
large Serratia entomophila plasmid, pADAP, have phage-related loci containing putative …

Insecticidal toxins from the Photorhabdus and Xenorhabdus bacteria

SJ Hinchliffe, MC Hares, AJ Dowling… - Open Toxinology …, 2010 - benthamopen.com
Insect pathogens are an excellent source of novel insecticidal agents with proven toxicity. In
particular, bacteria from the genera Photorhabdus and Xenorhabdus are proving to be a …

Structure and activation mechanism of the Makes caterpillars floppy 1 toxin

A Belyy, P Heilen, P Hagel, O Hofnagel… - Nature …, 2023 - nature.com
The bacterial Makes caterpillars floppy 1 (Mcf1) toxin promotes apoptosis in insects, leading
to loss of body turgor and death. The molecular mechanism underlying Mcf1 intoxication is …

MARTX, multifunctional autoprocessing repeats-in-toxin toxins

KJF Satchell - Infection and immunity, 2007 - Am Soc Microbiol
The repeats-in-toxin (RTX) exoproteins are a diverse collection of proteins exported via type
I secretion by gram-negative bacteria. These proteins include the pore-forming RTX toxins …

Multifunctional-autoprocessing repeats-in-toxin (MARTX) Toxins of Vibrios

KJF Satchell - Microbiology spectrum, 2015 - Am Soc Microbiol
Multifunctional-autoprocessing repeats-in-toxin (MARTX) toxins are a heterogeneous group
of toxins found in a number of Vibrio species and other Gram-negative bacteria. The toxins …

The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

I Vlisidou, A Hapeshi, JRJ Healey, K Smart, G Yang… - Elife, 2019 - elifesciences.org
Photorhabdus is a highly effective insect pathogen and symbiont of insecticidal nematodes.
To exert its potent insecticidal effects, it elaborates a myriad of toxins and small molecule …