Unfolding the cascade of SERPINA3: inflammation to cancer
Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …
SERPINA3: stimulator or inhibitor of pathological changes
M De Mezer, J Rogaliński, S Przewoźny, M Chojnicki… - Biomedicines, 2023 - mdpi.com
SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine
proteases, one of which is cathepsin G. As an acute-phase protein secreted into the plasma …
proteases, one of which is cathepsin G. As an acute-phase protein secreted into the plasma …
Evolution of enhanced innate immune evasion by SARS-CoV-2
LG Thorne, M Bouhaddou, AK Reuschl… - Nature, 2022 - nature.com
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance
human-to-human transmission,. Although much effort has focused on the characterization of …
human-to-human transmission,. Although much effort has focused on the characterization of …
Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
CovInter: interaction data between coronavirus RNAs and host proteins
K Amahong, W Zhang, Y Zhou, S Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Coronavirus has brought about three massive outbreaks in the past two decades. Each step
of its life cycle invariably depends on the interactions among virus and host molecules. The …
of its life cycle invariably depends on the interactions among virus and host molecules. The …
N6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice
X Wang, Y Ding, R Li, R Zhang, X Ge, R Gao… - Nature …, 2023 - nature.com
Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected
individuals. Controlling the excessive production of pro-inflammatory cytokines and …
individuals. Controlling the excessive production of pro-inflammatory cytokines and …
HCV infection increases the expression of ACE2 receptor, leading to enhanced entry of both HCV and SARS-CoV-2 into hepatocytes and a coinfection state
T Domovitz, S Ayoub, M Werbner, J Alter… - Microbiology …, 2022 - Am Soc Microbiol
Recent studies suggest the enhancement of liver injury in COVID-19 patients infected with
Hepatitis C virus (HCV). Hepatocytes express low levels of angiotensin-converting enzyme 2 …
Hepatitis C virus (HCV). Hepatocytes express low levels of angiotensin-converting enzyme 2 …
The SARS-CoV-2 targeted human RNA binding proteins network biology to investigate COVID-19 associated manifestations
The global coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2
virus has had unprecedented social and economic ramifications. Identifying targets for drug …
virus has had unprecedented social and economic ramifications. Identifying targets for drug …
SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses
A Arora, JE Kolberg, S Srinivasachar Badarinarayan… - Mobile DNA, 2023 - Springer
Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important
role in the host response to infection and the development of disease. By analyzing ChIP …
role in the host response to infection and the development of disease. By analyzing ChIP …
Impaired activation of transposable elements in SARS‐CoV‐2 infection
Emerging evidence shows that transposable elements (TEs) are induced in response to viral
infections. This TE induction is suggested to trigger a robust and durable interferon …
infections. This TE induction is suggested to trigger a robust and durable interferon …