The mechanism of drug nephrotoxicity and the methods for preventing kidney damage

E Kwiatkowska, L Domański, V Dziedziejko… - International Journal of …, 2021 - mdpi.com
Acute kidney injury (AKI) is a global health challenge of vast proportions, as approx. 13.3%
of people worldwide are affected annually. The pathophysiology of AKI is very complex, but …

Vancomycin-associated acute kidney injury: a narrative review from pathophysiology to clinical application

WC Kan, YC Chen, VC Wu, CC Shiao - International journal of molecular …, 2022 - mdpi.com
Vancomycin is the most frequently used antibiotic, accounting for up to 35% of hospitalized
patients with infection, because of its optimal bactericidal effectiveness and relatively low …

Vancomycin-Loaded Fe3O4/MOF-199 Core/Shell Cargo Encapsulated by Guanidylated−β-Cyclodextrine: An Effective Antimicrobial Nanotherapeutic

R Taheri-Ledari, N Tarinsun, F Sadat Qazi… - Inorganic …, 2023 - ACS Publications
This study describes an efficient antimicrobial drug delivery system composed of iron oxide
magnetic nanoparticles (Fe3O4 NPs) coated by an MOF-199 network. Then, the prepared …

Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity

E van Groesen, E Mons, I Kotsogianni, M Arts… - Science Translational …, 2024 - science.org
Gram-positive bacterial infections present a major clinical challenge, with methicillin-and
vancomycin-resistant strains continuing to be a cause for concern. In recent years …

Antimicrobial resistance in bacteria isolated from canine urine samples submitted to a veterinary diagnostic laboratory, Illinois, United States

S Yudhanto, CC Hung, CW Maddox… - Frontiers in Veterinary …, 2022 - frontiersin.org
The emergence of antimicrobial resistance (AMR) in dogs constitutes a threat to animal and
human health. There is a lack of studies in Illinois that evaluated the prevalence of AMR …

Vancomycin area under the curve–guided dosing and monitoring for adult and pediatric patients with suspected or documented serious methicillin-resistant …

TP Lodise, G Drusano - Clinical Infectious Diseases, 2021 - academic.oup.com
The revised vancomycin consensus guidelines recommended area under the curve (AUC)–
guided dosing/monitoring for patients with serious invasive methicillin-resistant …

Relationship of vancomycin trough levels with acute kidney injury risk: an exposure–toxicity meta-analysis

I Bellos, G Daskalakis… - Journal of Antimicrobial …, 2020 - academic.oup.com
Objectives Nephrotoxicity represents a major complication of vancomycin administration,
leading to high rates of morbidity and treatment failure. The aim of this meta-analysis was to …

[HTML][HTML] Overview of antibiotic-induced nephrotoxicity

RE Campbell, CH Chen, CL Edelstein - Kidney International Reports, 2023 - Elsevier
Drug-induced nephrotoxicity accounts for up to 60% of cases of acute kidney injury (AKI) in
hospitalized patients and is associated with increased morbidity and mortality in both adults …

Dapagliflozin improves early acute kidney injury induced by vancomycin in rats: Insights on activin A/miRNA-21 signaling and FOXO3a expression

SF Darwish, AMA Mahmoud, SSA Mageed… - European Journal of …, 2023 - Elsevier
Drug-induced acute kidney injury (AKI) represents a potentially serious disorder associated
with increased morbidity and mortality. The presented study investigated the ability of the …

Staphylococcus aureus persistence in osteocytes: weathering the storm of antibiotics and autophagy/xenophagy

NJ Gunn, SP Kidd, LB Solomon, D Yang… - Frontiers in Cellular …, 2024 - frontiersin.org
Staphylococcus aureus is a major causative pathogen of osteomyelitis. Intracellular
infections of resident bone cells including osteocytes can persist despite gold-standard …