The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Arteries and veins are specified by antagonistic transcriptional programs. However, during
development and regeneration, new arteries can arise from pre-existing veins through a …

In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like
network of cardiomyocytes that is critical for contraction and conduction, ventricular …

Complex genetic mechanisms are thought to underlie many human diseases, yet
experimental proof of this model has been elusive. Here, we show that a human cardiac …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

Highlights•Protein O-fucosyltransferases 1 and 2 (POFUT1 and POFUT2) are ER-localized
and modify EGF repeats and TSRs.•Both POFUT1 and POFUT2 are exquisitely selective for …

Fringe proteins are β3-N-acetylglucosaminyltransferases that modulate Notch activity by
modifying O-fucose residues on epidermal growth factor-like (EGF) repeats of Notch …

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in
children and its pathogenesis has been associated with the developmental defect of the …