SGLT2 inhibitors: an evidence-based update on cardiovascular implications

I Forzano, S Wilson, A Lombardi… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Sodium Glucose co-Transporter 2 (SGLT2) inhibitors (also known
as 'gliflozins') represent a cornerstone to treat diabetes mellitus. Moreover, recent …

Inflammation and Heart Failure: Searching for the Enemy—Reaching the Entelechy

I Paraskevaidis, D Farmakis, G Papingiotis… - Journal of …, 2023 - mdpi.com
The pivotal role of inflammation in the pathophysiology of heart-failure (HF) development
and progression has long been recognized. High blood levels of pro-inflammatory and …

[HTML][HTML] Functional lipids and cardiovascular disease reduction: a concise review

DO Omachi, ANA Aryee, JO Onuh - Nutrients, 2024 - mdpi.com
Functional lipids are dietary substances that may have an impact on human health by
lowering the risk of chronic illnesses and enhancing the quality of life. Numerous functional …

Glucose-lowering agents and risk of ventricular arrhythmias and sudden cardiac death: a comprehensive review ranging from sulphonylureas to SGLT2 inhibitors

AJ Scheen - Diabetes & Metabolism, 2022 - Elsevier
Type 2 diabetes is associated with a higher risk of cardiac arrhythmias, especially in
presence of cardiovascular disease and/or heart failure. Even if atrial fibrillation/flutter …

Effect of alpha-lipoic acid on rat ventricles and atria under LPS-induced oxidative stress

B Skibska, A Goraca, A Skibska, A Stanczak - Antioxidants, 2022 - mdpi.com
Alpha-lipoic acid (α-LA) is a disulfide compound and one of the most effective antioxidants.
Many studies have indicated positive effects of α-LA in the prevention of pathologic …

Distress-mediated remodeling of cardiac connexin-43 in a novel cell model for arrhythmogenic heart diseases

CM Wahl, C Schmidt, M Hecker, ND Ullrich - International Journal of …, 2022 - mdpi.com
Gap junctions and their expression pattern are essential to robust function of intercellular
communication and electrical propagation in cardiomyocytes. In healthy myocytes, the main …

Hypertension and arrhythmias: a clinical overview of the pathophysiology-driven management of cardiac arrhythmias in hypertensive patients

J Marazzato, F Blasi, M Golino, P Verdecchia… - Journal of …, 2022 - mdpi.com
Because of demographic aging, the prevalence of arterial hypertension (HTN) and cardiac
arrhythmias, namely atrial fibrillation (AF), is progressively increasing. Not only are these …

Severe mental illness: cardiovascular risk assessment and management

C Polcwiartek, K O'Gallagher, DJ Friedman… - European Heart …, 2024 - academic.oup.com
Patients with severe mental illness (SMI) including schizophrenia and bipolar disorder die
on average 15–20 years earlier than the general population often due to sudden death that …

Analysis of pathogenesis and drug treatment of chronic obstructive pulmonary disease complicated with cardiovascular disease

XF Li, CQ Wan, YM Mao - Frontiers in medicine, 2022 - frontiersin.org
Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent
airflow limitation, and is associated with abnormal inflammatory responses in the lungs to …

Simvastatin Reduces Doxorubicin-Induced Cardiotoxicity: Effects beyond Its Antioxidant Activity

M Pecoraro, S Marzocco, R Belvedere… - International Journal of …, 2023 - mdpi.com
This study aimed to evaluate if Simvastatin can reduce, and/or prevent, Doxorubicin (Doxo)-
induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then …