Simple Summary HER3 is a member of the HER family. In the past decade, HER3 has been
recognized as an important protein in allowing tumors to grow unchecked. This review …

Abstract Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …

Introduction The specific pathogenesis of ankylosing spondylitis (AS) remains unclear, and
our study aimed to investigate the possible pathogenesis of AS. Materials and Methods Two …

SORL1, the gene encoding the large multidomain SORLA protein, has emerged as only the
fourth gene that when mutated can by itself cause Alzheimer's disease (AD), and as a gene …

Human epidermal growth factor receptor-3 (ERBB3) is a member of the ERBB receptor
tyrosine kinases (RTKs) and is expressed in many malignancies. Along with other ERBB …

Background Exosome mediated mRNA delivery is a promising strategy for the treatment of
multiple diseases. However, the low yield of exosomes is a bottleneck for clinical translation …

The development of HER2-targeted therapies has led to a dramatic improvement in
outcomes for breast cancer patients. However, nearly all patients with metastatic HER2 …

Truncating genetic variants of SORL1, encoding the endosome recycling receptor SORLA,
have been accepted as causal of Alzheimer's disease (AD). However, most genetic variants …

Ovarian cancer (OC) has the worst prognosis among gynecological malignancies. Cisplatin
(CDDP) is one of the most commonly used treatments for OC, but recurrence and metastasis …

Glioblastoma (GBM) is a fatal malignancy caused by dysregulation of cellular signal
transduction. Internalization plays a key role in maintaining signalling balance. Previous …