The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …

Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …

A comprehensive understanding of endothelial cell lineage specification will advance
cardiovascular regenerative medicine. Recent studies found that unique epigenetic …

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …

Heterozygous mutations in MECOM (MDS1 and EVI1 complex locus) have been reported to
be causative of a rare association of congenital amegakaryocytic thrombocytopenia and …

Expression of the MECOM (also known as EVI1) proto-oncogene is deregulated by
chromosomal translocations in some cases of acute myeloid leukemia (AML) and is …

The PRDM family of proteins share a unique structure, with an N-terminal PR domain, which
has a potential methyltransferase activity, followed by a distinct number of zinc fingers at the …

Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …

Abstract Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues
leading to regulation of transcription and splicing programs. Although PRMT5 has emerged …

MicroRNA-22 (miR-22) is emerging as a critical regulator in organ development and various
cancers. However, its role in normal hematopoiesis and leukaemogenesis remains unclear …