Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Energy homeostasis during fasting or prolonged exercise depends on mitochondrial fatty
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …

In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …