The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …

There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

Microglia survey brain parenchyma, responding to injury and infections. Microglia also
respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this …

The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …