The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

Although inflammation has long been known as a localized protective reaction of tissue to
irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer
and its prognosis are very dependent on the affected tissue, body location, and stage at …

Inflammation is a protective response that develops against tissue injury and infection.
Chronic inflammation, on the other hand, is the key player in the pathogenesis of many …

The tissue composition of polyunsaturated fatty acids is important to health and depends on
both dietary intake and metabolism controlled by genetic polymorphisms that should be …

Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the
oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) …

Extensive research within the last half a century has revealed that cancer is caused by
dysregulation of as many as 500 different gene products. Most natural products target …